Arrhythmias & electrophysiology

Right ventricular function is a predictor for sustained ventricular tachycardia requiring anti-tachycardic pacing in arrhythmogenic ventricular cardiomyopathy: insight into transvenous vs. subcutaneous implantable cardioverter defibrillator insertion

EuropacePublished Retrospective cohort study

Authors' conclusion

VA event rates are high in ARVC patients with a majority having VT falling in the VF zone resulting in ICD shock(s).

Study context

Population
Arrhythmogenic right ventricular cardiomyopathy (ARVC) patients with ICDs20 (43.5%) secondary prevention
Participants
46 patients
Outcome
VA events during follow-up, by device therapy, and their predictors
Methodological detailssingle-centre, prospectively collated registry data
  • Single-centre
  • Prospectively collated registry data

Main finding

As reported in the abstract

VA events · follow-up 12.1 ± 6.9 years
Patients with VA events
31 (67.4%)
Ventricular fibrillation (VF)
n = 2, 6.5%
VT in VF zone resulting in ICD shock(s)
n = 14], 45.2%
VT resulting in anti-tachycardia pacing (ATP)
n = 10, 32.3%
Both VT resulting in ATP and ICD shock(s)
n = 5, 16.1%
Severely impaired right ventricular (RV) function as independent predictor of VT resulting in ATP, HR
16.80 (3.74-75.2); P < 0.001 (95% CI)
Predictive accuracy, AUC
0.88 (0.76-1.00); P < 0.001 (95% CI)

Observational data: associations, not effects.

Further findings

ATP success

ATP successful
34.5%

Safety

Lead failure rate
11/46, 23.9%

Original publication

Right ventricular function is a predictor for sustained ventricular tachycardia requiring anti-tachycardic pacing in arrhythmogenic ventricular cardiomyopathy: insight into transvenous vs. subcutaneous implantable cardioverter defibrillator insertion. Europace. Published 22 May 2023. doi:10.1093/europace/euad073

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