Risk factors associated with ventricular fibrillation during first ST-elevation myocardial infarction: Individual participant data analysis of 3 prospective case-control studies
Authors' conclusion
Family history of SD, history of AF, and anterior infarct location were all independently and additively associated with an increased risk of VF in patients with a first STEMI.
Study context
- Population
- Patients with a first ST-elevation myocardial infarction (STEMI) (aged 18–80 years) with ventricular fibrillation (VF) (cases) or without VF (controls) before revascularization1,807 cases and 2923 controls (median age 59 years, 20% women)
- Participants
- 1,807 vs 2,923
- Comparison
- Family history of SD, history of atrial fibrillation (AF), and anterior infarct location on the development of VF during the first STEMI
- Casesn = 1,807
- Controlsn = 2,923
- Outcome
- VF during first STEMI, by risk factor (adjusted)
Pooled result
As reported in the abstract
Odds ratio (95% CI)
Family history of SD
1.61(1.38–1.87)
Previous AF
1.95(1.22–3.11)
Anterior myocardial infarction
1.55(1.36–1.75)
Further pooled results
Effect modification (further investigation)
- Increased effect of family history with multiple SDs in the family
- Stronger effect of AF on VF developing within the first minutes of symptoms
- Effect of anterior infarctions modified by enzymatically determined infarct size
Original publication
Risk factors associated with ventricular fibrillation during first ST-elevation myocardial infarction: Individual participant data analysis of 3 prospective case-control studies. Heart Rhythm. Published 8 August 2025. doi:10.
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