HypertensionCase-control study
Risk of Dementia During Antihypertensive Drug Therapy in the Elderly
- Nested case-control study
- matched (sex, age, clinical status)
- population-based
Authors' conclusion
In the old fraction of the general population, antihypertensive drug treatment is associated with a lower risk of dementia. This was also the case in very old and frail patients.
Study context
- Population
- New users of antihypertensive drugs aged ≥65 years, Lombardy, Italy, starting 2009–201213,812 cases, 5 matched controls each
- Participants
- 215,547 users
- Comparison
- Low, intermediate and high vs very low exposure to antihypertensive drugs
- Outcome
- Dementia or Alzheimer's disease
- Follow-up
- Up to 2019
Main finding
As reported in the abstract
Dementia risk reduction vs very low exposure
Each group vs very low exposureRisk reduction (95% CI)
Low exposure
2%(−4% to 7%)
Intermediate exposure
12%(6%–17%)
High exposure
24%(19%–28%)
Observational data: associations, not effects.
Further findings
Dementia risk in very old (≥85 years) and frail patients (subgroups)
- Inverse association also present in very old and frail patients
Original publication
Risk of Dementia During Antihypertensive Drug Therapy in the Elderly. J Am Coll Cardiol. Published 25 March 2024. doi:10.1016/j.jacc.2024.01.030
Summarised from the published abstract; every number is checked against it