Arrhythmias & electrophysiology
Risk of incident atrial fibrillation after COVID-19 infection: A systematic review and meta-analysis
Pooled result · Incident AFResult — go to the resultHazard ratio 1.57 95% CI 1.24–1.99Authors' conclusion
Recovered COVID-19 patients have a higher risk of AF events compared with individuals from the general population.
Study context
- Population
- Patients recovered from COVID-19 infection vs noninfected patients (mean age 56.5 years; 63.0% male)
- Participants
- 19,478,173 patients5 observational studies
- Comparison
- Recovered COVID-19 vs noninfected
- Recovered COVID-19n = 5,692,510
- Outcome
- Incident AF
- Follow-up
- Mean 14.5 ± 3.2 months
Methodological detailsrandom effects model
- Random effects model
Pooled result
As reported in the abstract
Hazard ratio
1.57
95% CI 1.24–1.99
P < 0.0001
Recovered COVID-19vs Noninfected
HR 1.57 (95% CI 1.24–1.99); P < 0.0001
Further pooled results
Pooled incidence of new-onset atrial fibrillation (AF) · mean follow-up 14.5 ± 3.2 months
- Pooled incidence of new-onset AF
- 2.6% (95% CI, 1.8%-6.18%)
Heterogeneity (multivariable metaregression: age, male sex, hypertension, CAD, follow-up length)
- Explained a significant part of heterogeneity, R2 (P = .01)
- 54.3%
Original publication
Risk of incident atrial fibrillation after COVID-19 infection: A systematic review and meta-analysis. Heart Rhythm. Published 16 April 2024. doi:10.
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