Risk of Major Adverse Cardiovascular Events During Acute Streptococcus pneumoniae Infection in Chronic Obstructive Pulmonary Disease (COPD) Patients
Authors' conclusion
Pneumococcal infection in patients with COPD was associated with an increased risk of MACE within 14 days postinfection.
Study context
- Population
- Patients with COPD and a positive lower respiratory tract or blood culture for S pneumoniae who experienced a major adverse cardiovascular events (MACE), Denmark, 2010–2017267 analysed
- Participants
- 327 patients
- Exposure
- Risk interval vs control interval
- Outcome
- Incidence of MACE
- Follow-up
- 14 days after positive culture
Methodological detailsDanish nationwide register data
- Danish nationwide register data
Main finding
As reported in the abstract
MACE · within 14 days after infection
- 4.6-fold increased incidence of MACE with pneumococcal infection
- P < 0.001
Observational data: associations, not effects.
Further findings
- 9.1-fold increased incidence of acute MI
- P < 0.001
Original publication
Risk of Major Adverse Cardiovascular Events During Acute Streptococcus pneumoniae Infection in COPD Patients. JACC Adv. Published 22 September 2025. doi:10.
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