Temporal Trends in Cardiovascular Events After Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction
Main finding · MACE, defined as recurrent myocardial infarction, ischemic stroke, or cardiovascular deathResult — go to the resultAdjusted hazard ratio 0.67 95% CI 0.58–0.76Authors' conclusion
In Western Denmark, with a fully implemented pPCI strategy, the 1-year risk of MACE and its individual components declined gradually by one-third in pPCI-treated STEMI patients from 2003 to 2017.
Study context
- Population
- First-time PCI-treated patients undergoing primary percutaneous coronary intervention (pPCI) for STEMI in Western Denmark, 2003 to 2017
- Participants
- 18,540 first-time pPCI-treated STEMI patients
- Exposure
- Trends in 1-year risk of major adverse cardiovascular events (MACE) across 4 time periods (2003-2006, 2007-2010, 2011-2014, and 2015-2017), compared to those of an age- and sex-matched general population
- Outcome
- MACE, defined as recurrent myocardial infarction, ischemic stroke, or cardiovascular death
- Follow-up
- 1 year
Methodological detailscomparison with an age- and sex-matched general population
- Comparison with an age- and sex-matched general population
Main finding
As reported in the abstract
Adjusted hazard ratio
0.67
95% CI 0.58–0.76
By group
2015-2017vs 2003-2006
adjusted HR 0.67 (95% CI 0.58–0.76)
Observational data: associations, not effects.
Further findings
Individual components of MACE · 1 year
- Similar relative reductions were observed for the individual components of MACE
- Cardiovascular death was the most common outcome and the largest contributor to the absolute reduction in MACE
1-year risk of MACE, STEMI patients compared to the matched general population
- Higher 1-year risk of MACE in STEMI patients, 2003 to 2006
- 11%
- Risk difference, 2015 to 2017
- 7%
Original publication
Temporal Trends in Cardiovascular Events After Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction. JACC Adv. Published 20 February 2025. doi:10.
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