Valvular & structural heart disease
Risk of Myocardial Infarction in Patients With Aortic Stenosis: Insights From the VALVENOR Registry
Authors' conclusion
In patients with AS, the risk of MI is relatively low especially in patients without PCE and without angina. No association between the risk of MI and AS severity was observed. Although rare, incident MI is strongly associated with subsequent mortality.
Study context
- Population
- Outpatients with native valvular aortic stenosis (AS) (peak aortic jet velocity [Vmax] ≥2.5 m/s), enrolled between 2016 and 2017outpatients enrolled
- Participants
- 2,830 outpatients
- Exposure
- Risk of myocardial infarction (MI) across degrees of AS severity
- Outcome
- Baseline characteristics
Main finding
As reported in the abstract
Mean age
76.0 years
Men
54%
Prior coronary event (PCE)
18.3%
Observational data: associations, not effects.
Further findings
| Outcome | HR | P value |
|---|---|---|
| Incident MI as predictor of mortalityAfter adjustment | 2.00 | P < 0.001 |
Cumulative incidence of MI (death as competing event) · 5 years
- Cumulative incidence of MI
- 2.5%
- n
- 72
- ST-segment elevation MI
- one-third
Correlates of MI
- PCE and angina symptoms associated with an increased risk
- Female gender associated with a decreased risk
- AS severity was not associated with the risk of MI
Subsequent mortality after MI · median 648 days after MI occurrence
- Subsequent mortality
- 52.8%
Original publication
Risk of Myocardial Infarction in Patients With Aortic Stenosis: Insights From the VALVENOR Registry. JACC Adv. Published 25 April 2025. doi:10.
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