Heart failure & cardiomyopathies
Risk prediction in patients with heart failure with preserved ejection fraction: the LIFE-Preserved model
Authors' conclusion
The LIFE-Preserved model enables prediction of short-term and lifetime risk of HF hospitalization or CV death in patients with HFpEF.
Study context
- Population
- Patients aged 40–90 years with HFpEF (LVEF ≥ 50%), Swedish heart failure (HF) Registry (derivation)derivation cohort
- Participants
- 20,332 patients
- Comparison
- Trials vs Registries
- Outcome
- HF hospitalization or CV death (model discrimination and calibration)
Methodological detailscause- and sex-specific Cox models, age as timescale, adjusted for competing risks, external validation in 2 trials and 3 registries
- Cause- and sex-specific Cox models
- Age as timescale
- Adjusted for competing risks
- External validation in 2 trials and 3 registries
Performance
As reported in the abstract
Pooled C-statistic, external validation (HF hospitalization or CV death)
Trials
.714
pooled C-statistic · 95% CI .652-.775
Registries
.658
pooled C-statistic · 95% CI .599-.717
Further findings
HF hospitalization or cardiovascular (CV) death, derivation cohort · median follow-up 1.8 years (IQR .6-4.2, maximum 19 years)
- First HF hospitalizations or CV deaths, Swedish HF Registry
- 9341 (46%)
- First HF hospitalizations or CV deaths, external validation
- 9930 (35%)
Model performance by sex
- Performance similar in men and women
Original publication
Risk prediction in patients with heart failure with preserved ejection fraction: the LIFE-Preserved model. Eur Heart J. Published 11 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →