Arrhythmias & electrophysiology
S-ICD Implantation Following TV-ICD: Insights Into Patients With Infections and Abandoned Leads: The HONEST Cohort
Authors' conclusion
Rescue S-ICD implantation is an acceptable option for patients with device-related complications. Lead abandonment in the setting of a noninfective indication appears to be safe. (S-ICD French Cohort Study [HONEST]; NCT05302115).
Study context
- Population
- Patients with transvenous ICDs experiencing complications undergoing rescue S-ICD implantation, compared with de novo S-ICD patients, in the HONEST cohortpatients in the HONEST cohort, 651 underwent rescue S-ICD implantation · rescue S-ICD 651 · rescue S-ICD with infective indications 295 · rescue S-ICD with abandoned leads 244
- Participants
- 4,924 patients
- Exposure
- Outcomes were compared between rescue and de novo S-ICD patients
- Rescue S-ICDn = 651
- Outcome
- Complications
- Follow-up
- 4.2 ± 2.2 years
Methodological detailsFrench
- French
Main finding
As reported in the abstract
P = 0.35
Observational data: associations, not effects.
Further findings
Reinterventions · follow-up of 4.2 ± 2.2 years · similar
P = 0.17
Mortality · follow-up of 4.2 ± 2.2 years · higher in rescue
P < 0.001
- Mortality: mainly due to a higher burden of comorbidities, as none of these parameters was independently associated with mortality in multivariate analyses
Complications and reinterventions, infective vs noninfective rescue S-ICD (subgroup)
- Complications, infective vs noninfective
- 21.6% vs 23.5%; P = 0.55
- Reinterventions, infective vs noninfective
- 8.9% vs 8.6%; P = 0.90
Complications and reinterventions, abandoned vs extracted leads (subgroup)
- Complications, abandoned vs extracted leads
- 24.3% vs 21.7%; P = 0.46
- Reinterventions, abandoned vs extracted leads
- 8.3% vs 9.0%; P = 0.77
Mortality, rescue S-ICD subgroups
- Higher with infective indications
- 29.2% vs 6.7%; P < 0.001
- Higher with extracted leads
- 21.9% vs 8.6%; P < 0.001
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →