Arrhythmias & electrophysiology
Safety and Efficacy of Combining Left Atrial Appendage Occlusion With Another Cardiac Procedure
Main finding · MACE (risk-adjusted)Result — go to the resultAdjusted odds ratio 1.82 95% CI 0.94–2.74Authors' conclusion
In this retrospective observational study, combining LAAO with another cardiac intervention appeared to be associated with similar MACEs and LOS. However, certain complications appeared to be more frequent, and the cost was higher with combined procedures.
Study context
- Population
- Patients undergoing Left Atrial Appendage Occlusion (LAAO), US National Inpatient Sample 2016–2020
- Participants
- 88,910 weighted encounters
- Exposure
- LAAO combined with another cardiac procedure vs isolated LAAO
- Concomitant proceduren = 1,225
- Outcome
- MACE (risk-adjusted)
- Follow-up
- In-hospital
Methodological detailsNational Inpatient Sample 2016–2020, risk-adjusted
- National Inpatient Sample 2016–2020
- Risk-adjusted
Main finding
As reported in the abstract
Adjusted odds ratio
1.82
95% CI 0.94–2.74
Concomitant procedurevs Isolated LAAO
adjusted OR 1.82 (95% CI 0.94–2.74)
Observational data: associations, not effects.
Further findings
Length of stay
P = 0.32
| Outcome | Concomitant procedure | Isolated LAAO | P value |
|---|---|---|---|
| Total costs | $44,723 | $32,364 | P < 0.01 |
- Length of stay (LOS) and costs vs LAAO with sequential procedures · LOS 1 day vs 2 days
- P < 0.01
- LOS and costs vs LAAO with sequential procedures · costs $51,552 vs $63,170
- P = 0.04
In-hospital mortality and complications (stroke, AKI, major bleeding, transfusion, vascular injury)
- Similar adjusted odds vs isolated LAAO
Safety
Complications by concomitant procedure (subgroups)
- Concomitant AF/atrial flutter ablation: higher adjusted odds of heart block
- P < 0.01
- Concomitant TAVR: higher adjusted odds of stroke
- P = 0.02
- Concomitant TAVR: higher adjusted odds of vascular injury
- P < 0.01
Original publication
Safety and Efficacy of Combining Left Atrial Appendage Occlusion With Another Cardiac Procedure. JACC Cardiovasc Interv. Published 22 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →