Arrhythmias & electrophysiology
Safety and Efficacy of Left Atrial Ablation After Percutaneous Left Atrial Appendage Occlusion in High-Bleeding-Risk Patients with Atrial Fibrillation: A Multicenter Analysis from the PROCEED-AF Ablation Registry
Authors' conclusion
In a large, international registry of patients undergoing catheter ablation for AF with pre-existing LAAO devices, ablation was feasible and device related complications were rare Despite higher bleeding risk in an LAAO population, 84% of patients with prior LAAO tolerated short term OAC post-ablation with bleeding events at expected rates for this population.
Study context
- Population
- Patients with prior LAAO devices undergoing atrial fibrillation (AF) ablation
- Participants
- 198 patients
- Outcome
- Safety and efficacy of AF ablation after LAAO
Methodological detailsinternational registry, 14 centres
- International registry
- 14 centres
Main finding
As reported in the abstract
Ablation performed after LAAO (median)
271 days
On oral anticoagulation (OAC) after ablation (most commonly for 2-3 months)
84%
Stroke or TIA during follow-up
5 patients
2.6% of cases
Stroke or TIA the day after ablation
2 occurrences
1% of cases
Observational data: associations, not effects.
Safety
Bleeding complications on OAC · median of 20 (13, 70) days after ablation
- Bleeding complications on OAC
- 6.7%
New or worsened peri-device leak after ablation
- New or worsened peri-device leak
- 2 cases
Original publication
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