Arrhythmias & electrophysiology
Outcomes of Left Atrial Appendage Occlusion in Patients With Prior Gastrointestinal Bleeds
Main finding · In-hospital major complications (adjusted)Result — go to the resultOdds ratio 1.18 95% CI 1.10–1.26Authors' conclusion
Patients with prior GIB undergoing LAAO experienced higher in-hospital complications and long-term risks for GIB and major bleeding, with no differences in stroke risk.
Study context
- Population
- Patients undergoing Watchman Left Atrial Appendage Occlusion (LAAO) in the NCDR LAAO Registry, January 2016–December 2022prior gastrointestinal bleeding (GIB) 33.7%
- Exposure
- Prior GIB vs no prior GIB in patients undergoing Watchman LAAO
- Outcome
- In-hospital and long-term adverse events, mortality and postimplantation antithrombotic prescriptions
Methodological detailsregistry-based
- Registry-based
Main finding
In-hospital major complications (adjusted)
Odds ratio
1.18
95% CI 1.10–1.26
Prior GIBvs Non-GIB
OR 1.18 (95% CI 1.10–1.26)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Death · 1 year
- Prior GIB vs no prior GIB: higher risk of death
- HR: 1.10; 95% CI: 1.06-1.14
Stroke
- Stroke risk no different between groups
Safety
| Outcome | OR (95% CI) | |
|---|---|---|
| In-hospital major complicationsAfter adjustment | 1.18 (1.10–1.26) | |
| 0.512Odds ratio (log scale) |
GIB · 45 days
- Prior GIB vs no prior GIB: increased risk of GIB
- HR: 4.36; 95% CI: 4.07-4.66
Major bleeding · 45 days
- Prior GIB vs no prior GIB: increased risk of major bleeding
- HR: 2.94; 95% CI: 2.74-3.16
GIB · 1 year
- Prior GIB vs no prior GIB: higher risk of GIB
- HR: 3.84; 95% CI: 3.65-4.03
Major bleeding · 1 year
- Prior GIB vs no prior GIB: higher risk of major bleeding
- HR: 2.82; 95% CI: 2.67-2.98
Original publication
Outcomes of Left Atrial Appendage Occlusion in Patients With Prior Gastrointestinal Bleeds. JACC Clin Electrophysiol. Published 31 October 2025. doi:10.
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