Heart failure & cardiomyopathies
Salt Substitute Recommendations for Heart Failure Patients May Influence Guideline-Directed Medical Therapies Titration
Authors' conclusion
Beyond the well-established risk for hyperkalaemia, our preliminary results suggest a potentially negative impact of saltSubs on GDMT use, especially for ACEis/ARBs/ARNis in CHF management.
Study context
- Population
- Patients with chronic HF, their caregivers and healthcare professionals (HCPs) in France, September 2020 to July 2021
- Exposure
- SaltSub recommendation vs no saltSub recommendation
- Outcome
- HCP recommendations and reported use of salt substitutes
Methodological detailsnationwide, questionnaire-based, epidemiological
- Nationwide
- Questionnaire-based
- Epidemiological
Main finding
As reported in the abstract
HCPs advising saltSubs
13%
Patients reporting saltSub use
17%
Caregivers reporting saltSub use
22%
Observational data: associations, not effects.
Secondary outcomes
ACEi/ARB/ARNi use, saltSub recommendation vs none (overall population)
- Less frequent with saltSub recommendations
- 74% vs. 82%, P = 0.012
MRA and BB use, saltSub recommendation vs none
- MRA: no significant difference
- 56% vs. 58%
- BB: no significant difference
- 78% vs. 82%
ACEi/ARB/ARNi under-prescription with saltSub recommendations, by ejection fraction (EF) (subgroup)
- EF < 40%
- P = 0.029
- EF ≥ 40%
- P = 0.043
Thiazide and low EF GDMT use with saltSub recommendations, LVEF ≥ 40% (subgroup)
- Higher thiazide use
- P = 0.014
- Less frequent use of low EF guideline-directed medical therapies (GDMTs)
- P = 0.044
Characteristics of patients advised saltSubs
- No difference in EF <40%, ischaemic origin or NYHA III-IV; more recently hospitalized for acute HF
- P = 0.004
Other advice by HCPs recommending saltSubs
- Anti-diabetic diet more likely
- P < 0.001
- Cholesterol-lowering diet more likely
- P < 0.001
- Exercise more likely
- P = 0.018
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →