Arrhythmias & electrophysiology
SCN5A gene variants and arrhythmic risk in Brugada syndrome: An updated systematic review and meta-analysis
Pooled result · Major arrhythmic eventsResult — go to the resultOdds ratio 2.14 95% CI 1.53–2.99Authors' conclusion
SCN5A+ BrS patients showed a worse clinical phenotype compared with SCN5A-. The pooled analysis demonstrated a significant association between SCN5A+ mutation status and the risk of major arrhythmic events in BrS patients.
Study context
- Population
- Patients with Brugada syndrome with SCN5A genetic testing and reported arrhythmic outcomes
- Participants
- 3,568 patients17 studies
- Comparison
- SCN5A+ vs SCN5A- Brugada syndrome
- Outcome
- Major arrhythmic events
Methodological detailsPubMed and CENTRAL searched from inception to January 2024
- PubMed and CENTRAL searched from inception to January 2024
Pooled result
As reported in the abstract
Odds ratio
2.14
95% CI 1.53–2.99
SCN5A+vs SCN5A-
OR 2.14 (95% CI 1.53–2.99)
Further pooled results
Clinical phenotype
- SCN5A+ more frequently had spontaneous type 1 ECG, history of syncope and documented arrhythmias
- Higher PQ and QRS intervals in SCN5A+
Original publication
SCN5A gene variants and arrhythmic risk in Brugada syndrome: An updated systematic review and meta-analysis. Heart Rhythm. Published 16 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →