Heart failure & cardiomyopathies
Seattle proportional risk model in GISSI-HF: Estimated benefit of implantable cardioverter-defibrillator (ICD) in patients with EF less than 50%
Authors' conclusion
The SPRM discriminated SCD vs non-SCD in GISSI-HF, both in patients with EF ≤35% and with EF 36% to 50%.
Study context
- Population
- Heart failure (HF) patients with EF ≤50% in the GISSI-HF trial
- Participants
- 6,750 patients
- Comparison
- Seattle Proportional Risk Model (SPRM)-predicted proportion of sudden cardiac death (SCD) ≥50% vs <50%
- Primary endpoint
- Accuracy of the SPRM in predicting SCD vs non-SCD and potential ICD benefit
Primary result
As reported in the abstract
SCD vs non-SCD prediction by SPRM · 1 year
SPRM predicted SCD vs non-SCD, OR
1.92
P < 0.0001
Estimated proportion of SCD
44%
Observed proportion of SCD
41%
Further findings
| Outcome | EF ≤35% | EF 36% to 50% |
|---|---|---|
| SPRM ≥50%, by EF | Fifty percent | 43% |
| Estimated ICD HR (SPRM ≥50%) | 0.64 | 0.65 |
Deaths
- All-cause deaths
- 1,892
- SCDs
- 610
ICD eligibility
- Eligible by traditional criteria (EF ≤35%, NYHA II or III)
- 64.5%
- Estimated ICD benefit, traditional criteria
- 0.81
- Eligible by SPRM >50%
- 47.8%
- Of which EF >35%
- 30.2%
Original publication
Seattle proportional risk model in GISSI-HF: Estimated benefit of ICD in patients with EF less than 50%. Am Heart J. Published 31 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →