Coronary disease & ACS

Selective C-reactive protein apheresis in ST-elevation myocardial infarction: Design and rationale of the randomized CRP-STEMI trial

Am Heart JPublished investigator-initiated, randomized, open-label (outcome assessor blinded), multicenter trial

Study context

Population
ST-elevation myocardial infarction (STEMI) patients undergoing percutaneous coronary intervention (PCI) within 12 hours of symptom onsetplanned enrolment
Participants
202 patients
Planned comparison
Selective C-reactive protein (CRP) apheresis using the PentraSorb-CRP system, in addition to standard care, vs standard care
Primary endpoint
infarct size as assessed by late gadolinium enhanced cardiac magnetic resonance
Follow-up
5 ± 2 days after PCI
Methodological detailsdesign and rationale paper, 5 tertiary care centers in Austria and Germany
  • Design and rationale paper
  • 5 tertiary care centers in Austria and Germany

No results yet. This paper sets out the design of a trial; its results are to come.

Original publication

Selective C-reactive protein apheresis in ST-elevation myocardial infarction: Design and rationale of the randomized CRP-STEMI trial. Am Heart J. Published 28 July 2025. doi:10.1016/j.ahj.2025.07.067

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