Heart failure & cardiomyopathies
Serially Measured Metabolic Plasma Biomarkers and Adverse Outcomes in Chronic Heart Failure: A Longitudinal NMR Spectroscopy Study in Two Cohorts
Authors' conclusion
Serially measured nuclear magnetic resonance-derived lipoprotein and metabolic biomarkers were associated with the primary end point in chronic stable HF. These findings support further evaluation of serial metabolic profiling as a complementary approach to risk assessment in HF.
Study context
- Population
- Patients with chronic stable heart failure (HF) in 2 independent cohorts with serial blood sampling (Bio-SHiFT and TRIUMPH)2 independent HF cohorts
- Participants
- 382 vs 233
- Exposure
- Associations between current levels of serially measured biomarkers and the cohort-specific primary end point
- Bio-SHiFTn = 382
- TRIUMPHn = 233
- Outcome
- Composite of:
- HF hospitalization
- Advanced HF therapy
- Cardiovascular death (cohort-specific primary end point)
Methodological detailsserial blood sampling, joint models, adjusted for relevant clinical covariates
- Serial blood sampling
- Joint models
- Adjusted for relevant clinical covariates
Main finding
As reported in the abstract
Hazard ratio, per Z score of natural log-transformed biomarker (95% CI)
S-high-density lipoprotein particleBio-SHiFT; higher current levels associated with lower risk
0.59(0.45–0.78)
High-density lipoprotein subclass 2 particlelower risk
0.57(0.42–0.80)
Total high-density lipoprotein particlelower risk
0.54(0.41–0.70)
Mean high-density lipoprotein particle sizegreater size associated with higher risk
1.52(1.23–1.87)
Inflammation vulnerability indexhigher risk
3.11(2.07–4.88)
Metabolic malnutrition indexhigher risk
1.98(1.38–2.96)
Metabolic vulnerability indexhigher risk
3.79(2.43–5.98)
Per Z score of natural log-transformed biomarker, as printed
Observational data: associations, not effects.
Original publication
Serially Measured Metabolic Plasma Biomarkers and Adverse Outcomes in Chronic Heart Failure: A Longitudinal NMR Spectroscopy Study in Two Cohorts. Circ Heart Fail. Published 6 August 2026. doi:10.
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