Heart failure & cardiomyopathies
Serum Chloride and the Response to Acetazolamide in Patients With Acute Heart Failure and Volume Overload: A Post Hoc Analysis From the ADVOR Trial
Authors' conclusion
Hypochloremia is associated with diuretic resistance and worse clinical outcomes. Add-on acetazolamide therapy improves decongestion across the entire range of serum chloride and prevents the drop in chloride levels caused by loop diuretic monotherapy.
Study context
- Population
- Patients with acute decompensated HF and volume overload
- Participants
- 519 patients
- Comparison
- IV acetazolamide vs placebo on top of IV loop diuretics, by baseline serum chloride
- Primary endpoint
- Impact of baseline serum chloride on main trial end points and on the treatment effect of acetazolamide
Methodological detailspost hoc analysis
- Post hoc analysis
Primary result
As reported in the abstract
Baseline serum chloride: prevalence and association with outcomes and acetazolamide effect
Hypochloremia (<96 mmol/L) at baseline
80
15%
Hyperchloremia (>106 mmol/L) at baseline
53
10%
Further findings
Evolution of serum chloride under decongestive treatment
- Progressive decline in serum chloride with placebo, effectively prevented by acetazolamide
- P < 0.001
Original publication
Serum Chloride and the Response to Acetazolamide in Patients With Acute Heart Failure and Volume Overload: A Post Hoc Analysis From the ADVOR Trial. Circ Heart Fail. Published 22 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →