Serum Lipoproteins Are Associated With Coronary Atherosclerosis in Asymptomatic U.S. Adults Without Traditional Risk Factors
Authors' conclusion
Among asymptomatic middle-aged adults without traditional risk factors, coronary atherosclerosis is common and increasingly prevalent at higher levels of atherogenic lipoproteins.
Study context
- Population
- Asymptomatic adults aged 40–65 y in the Miami Heart Study, not on lipid-lowering therapy, without hypertension, DM or active tobacco use55.0% women
- Participants
- 1,033 adults
- Exposure
- Atherosclerosis prevalence by serum low-density lipoprotein cholesterol (LDL-C), non-HDL-C and apolipoprotein B (apoB) levels
- Outcome
- Coronary atherosclerosis on coronary CT angiography
Methodological detailsMultivariable logistic regression with forward selection
- Multivariable logistic regression with forward selection
Main finding
As reported in the abstract
Coronary atherosclerosis
Adjusted odds ratio (95% CI)
Higher LDL-Cper 10 mg/dL
1.13(1.08–1.18)
Ageper 5 years
1.43(1.28–1.60)
Male sex
3.81(2.86–5.10)
Elevated lipoprotein(a)
1.46(1.01–2.09)
Each row per its own increment, as printed
- Overall prevalence of coronary atherosclerosis
- 35.9%
- Men
- 50.6%
- Women
- 23.8%
- ≥1 high-risk plaque feature
- 3.4%
Observational data: associations, not effects.
Further findings
Atherosclerosis in adults with optimal risk factors
- Prevalence, greater at higher lipoprotein levels
- 21.2%
Original publication
Serum Lipoproteins Are Associated With Coronary Atherosclerosis in Asymptomatic U.S. Adults Without Traditional Risk Factors. JACC Adv. Published 13 June 2024. doi:10.
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