Severe Infection and Risk of Cardiovascular Disease: A Multicohort Study
Authors' conclusion
Infections severe enough to require hospital treatment were associated with increased risks for major cardiovascular disease events immediately after hospitalization. A small excess risk was also observed in the long-term, but residual confounding cannot be excluded.
Study context
- Population
- UK Biobank participants without CVD at baseline (2006–2010); replication in 3 Finnish prospective cohorts of community-dwelling participants (baseline 1986–2005)replication n = 271,329
- Participants
- 331,683 participants
- Exposure
- Hospitalisation for infection vs no record of infectious disease
- Hospitalized for infectionn = 54,434
- Outcome
- Major CV events (UK Biobank)
Methodological detailsmulticohort, independent replication cohort
- Multicohort
- Independent replication cohort
Main finding
As reported in the abstract
- Incident major CV event at follow-up
- 11 649
Observational data: associations, not effects.
Further findings
Replication cohort (3 Finnish cohorts): major CV events after hospitalization for infection
- Findings similar in the replication cohort
Population-attributable fraction of severe infections for major CV events (adjusted for traditional CV risk factors)
- UK Biobank
- 4.4%
- Replication cohort
- 6.1%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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