Valvular & structural heart disease
Sex-Based Differences in Long-Term Outcomes Following Transcatheter Closure of Patent Foramen Ovale for Cryptogenic Stroke
Authors' conclusion
No sex-based differences in recurrent cerebrovascular events, survival, or new-onset atrial fibrillation were observed in this study, suggesting equal benefits for both sexes.
Study context
- Population
- Patients undergoing transcatheter patent foramen ovale closure to prevent recurrent cerebrovascular events, Ontario
- Participants
- 783 patients
- Exposure
- Women vs men after transcatheter PFO closure
- Womenn = 349
- Menn = 434
- Outcome
- Long-term outcomes by sex: recurrent cerebrovascular events, survival, new-onset AF
- Follow-up
- Median 14 years
Methodological detailssingle-centre, linked to population-based administrative health databases
- Single-centre
- Linked to population-based administrative health databases
Main finding
As reported in the abstract
Recurrent cerebrovascular events, survival, new-onset AF
- Event rates of recurrent cerebrovascular events, survival and new-onset AF not different by sex
Observational data: associations, not effects.
Further findings
Procedural and 30-day outcomes
- No differences by sex
Safety
| Outcome | HR (95% CI) | |
|---|---|---|
| Pacemaker implantation · median follow-up 14 yearsAdjusted analysis; higher in men · adjusted analysis | 5.62 (1.57–20.1) | |
| 0.050.21520Hazard ratio (log scale) |
Original publication
Sex-Based Differences in Long-Term Outcomes Following Transcatheter Closure of Patent Foramen Ovale for Cryptogenic Stroke. Circ Cardiovasc Interv. Published 19 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →