Sex-Based Differences in Severe Outcomes, Including Cardiovascular Hospitalization, in Adults With COVID-19 in Ontario, Canada
Study context
- Population
- Community-dwelling adults in Ontario testing positive for SARS-CoV-2 during the first 3 waves30,736, 199,132 and 186,131 by wave
- Exposure
- Men vs women, by age
- Outcome
- Composite of severe outcomes (hospitalization for CV event, ICU admission, mechanical ventilation, or death)
- Follow-up
- 30 days
Main finding
As reported in the abstract
Composite severe outcome:
- CV hospitalization
- ICU admission
- Mechanical ventilation
- Death
- Severe outcome among 30,736 adults testing positive in the first wave
- 1,908 (6.2%)
- Severe outcome among 199,132 adults testing positive in the second wave
- 5,437 (2.7%)
- Severe outcome among 186,131 adults testing positive in the third wave
- 5,653 (3.0%)
- Sex-specific risk depended on age for all outcomes
- all P for interaction <0.05
Observational data: associations, not effects.
Further findings
All-cause hospitalization, ages 18-45 years (waves 2 and 3)
- Higher for young women than men
Cardiovascular (CV) hospitalization, sex disparity across waves
- Sex disparity across all ages persisted or increased with each subsequent wave
Original publication
Sex-Based Differences in Severe Outcomes, Including Cardiovascular Hospitalization, in Adults With COVID-19 in Ontario, Canada. JACC Adv. Published 10 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →