Aortic & peripheral vascular disease
Sex differences in ascending aortic diameter at the time of acute type A aortic dissection
Authors' conclusion
Female sex was associated with ATAAD at a smaller absolute diameter, an association that resolved when accounting for women’s smaller body size . Sex-specific guidelines for ascending aneurysm repair or guidelines accounting for body size may reduce preventable complications among women.
Study context
- Population
- Adult patients undergoing repair of spontaneous acute type A aortic dissection (ATAAD), 2011–2023146 (35.4%) female
- Participants
- 413 patients
- Exposure
- Maximum diameter and diameter indexed to height and body surface area (BSA) were compared by sex
- Womenn = 146
Methodological detailsconsecutive adult patients
- Consecutive adult patients
Main finding
As reported in the abstract
P < 0.001
Observational data: associations, not effects.
Further findings
Aortic diameter at the time of dissection · smaller in women
P = 0.035
Aortic diameter indexed to height · larger in women
P = 0.001
Aortic diameter indexed to BSA · larger in women
P < 0.001
| Outcome | β (95% CI) | P value |
|---|---|---|
| Association of female sex with aortic diameter (multivariable linear regression) · adjusted for comorbidities; smaller diameter with female sex | −1.77 (−3.12 to −0.42) | P = 0.010 |
Association of female sex with aortic diameter (multivariable linear regression)
- This association disappeared after adjusting for height and BSA
Original publication
Summarised from the published abstract; every number is checked against it