Sex Differences in Cardiac Structure and Function Following Acute Myocardial Infarction: Insights from the PARADISE-MI Echocardiographic Substudy
Authors' conclusion
Despite baseline differences in measures of cardiac function between men and women following acute high-risk MI, there were no significant sex-related changes in chamber size or LV function. Sex did not modify the association between echocardiographic parameters and clinical outcome.
Study context
- Population
- Patients randomised to sacubitril/valsartan or ramipril within 0.5 to 7 days of high-risk myocardial infarction (MI), with echocardiography at randomisation and after 8 months
- Participants
- 544 patients
- Comparison
- Women vs men
- Primary endpoint
- Primary composite outcome:
- CV death
- Incident HF
Methodological detailspre-specified echocardiographic substudy
- Pre-specified echocardiographic substudy
Primary result
As reported in the abstract
- At baseline, women had higher LV ejection fraction (LVEF) and lower LV end-diastolic volume (LVEDV) index, LV end-systolic volume (LVESV) index and left ventricular (LV) mass index
- After adjustment, changes in these echocardiographic parameters from baseline to 8 months were not significantly different in women vs men
- Sex did not modify the relationship between echocardiographic parameters and clinical outcome
Further findings
Echocardiographic parameters and primary composite outcome (CV death or incident HF)
- Lower LVEF, higher LVEDV, LVESV, left atrial volume index and average E/e' associated with higher risk of the primary composite outcome
Original publication
Sex Differences in Cardiac Structure and Function Following Acute Myocardial Infarction: Insights from the PARADISE-MI Echocardiographic Substudy. Eur J Heart Fail. Published 24 September 2024. doi:10.
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