Valvular & structural heart disease
Sex Differences in Outcomes After Transcatheter Aortic Valve Replacement: A POPular TAVI Subanalysis
Authors' conclusion
After TAVR, overall bleeding and ischemic outcomes were similar between women and men. However, women had more major or life-threatening bleedings, especially those receiving aspirin pre- and post-TAVR.
Study context
- Population
- Patients undergoing transcatheter aortic valve replacement (TAVR) in the POPular TAVI trial (aspirin or oral anticoagulant (OAC) monotherapy vs addition of clopidogrel)466 [47.6%] women
- Participants
- 978 patients
- Comparison
- Women vs men
- Womenn = 466
- Primary endpoint
- 1) All bleeding; 2) composite of ischemic events (stroke and MI)
Primary result
As reported in the abstract
| Group | Value | All bleeding | Ischemic events |
|---|---|---|---|
| Women | 22.8% | 106 [22.8%] | 26 [5.6%] |
| Men | 23.6% | 121 [23.6%] | 36 [7.0%] |
Value
Women22.8%
Men23.6%
All bleeding
Women106 [22.8%]
Men121 [23.6%]
Ischemic events
Women26 [5.6%]
Men36 [7.0%]
- Women vs Men: P = 0.815 — all bleeding
- Women vs Men: P = 0.429 — ischemic events (MI and stroke)
Safety
Major or life-threatening bleeding · mostly access site bleedings
P = 0.011
Major or life-threatening bleeding
- Aspirin pre- and post-TAVR increased major or life-threatening bleeding in women but not in men
Original publication
Sex Differences in Outcomes After Transcatheter Aortic Valve Replacement: A POPular TAVI Subanalysis. JACC Cardiovasc Interv. Published 8 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →