Sex Differences in Patients Undergoing FFR-Guided Percutaneous Coronary Intervention (PCI) or CABG in the FAME 3 Trial
Authors' conclusion
In the FAME 3 trial, at 3 years, women had similar outcomes with FFR-guided PCI compared with CABG, whereas men had improved outcomes with CABG.
Study context
- Population
- Patients with 3-vessel CAD265 (17.7%) women
- Participants
- 1,500 patients
- Comparison
- Fractional flow reserve (FFR)-guided PCI with current-generation drug-eluting stents (DES) vs CABG, by sex
- Primary endpoint
- Major adverse cardiac and cerebrovascular events (MACCE):
- All-cause death
- MI
- Stroke
- Repeat revascularization
- Follow-up
- 3 years
Methodological detailsprespecified subgroup analysis, investigator-initiated
- Prespecified subgroup analysis
- Investigator-initiated
Primary result
As reported in the abstract
MACCE by sex
PCI vs CABGAdjusted hazard ratio (95% CI)
Women
1.15(0.62–2.11)
Men
1.68(1.25–2.25)
Further findings
| Outcome | Women | Men | Adjusted HR (95% CI) | |
|---|---|---|---|---|
| MACCE, women vs men, after CABG · 3 years | 18.1% | 11.7% | 2.07 (1.19–3.60) | |
| MACCE, women vs men, after PCI · 3 years | 18.2% | 19.1% | 1.27 (0.79–2.03) | |
| MI in men | 2.11 (1.26–3.56) | |||
| Repeat revascularization in men | 2.26 (1.47–3.47) | |||
| 0.20.5125Adjusted hazard ratio (log scale) |
- MI in men: Pinteraction = 0.102
- Repeat revascularization in men: Pinteraction = 0.071
Original publication
Sex Differences in Patients Undergoing FFR-Guided PCI or CABG in the FAME 3 Trial. JACC Cardiovasc Interv. Published 4 December 2024. doi:10.
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