Heart failure & cardiomyopathies
Sex differences in the prevalence and prognosis of tricuspid regurgitation among patients with heart failure
Authors' conclusion
A higher TR prevalence was observed in women compared with men without differences in TR aetiology. Severe TR may predict mortality in female patients with pEF and male patients with rEF, but not vice versa. These results may have an impact on sex-specific follow-up and treatment strategies.
Study context
- Population
- Patients with heart failure (HF) with a recent transthoracic echocardiographypatients with HF prospectively enrolled between 2020 and 2022, including 38% women
- Participants
- 1,012 patients
- Exposure
- Sex differences in tricuspid regurgitation (TR) prevalence, aetiology and prognosis among patients with HF
- Outcome
- HF phenotype by sex
Methodological detailsprospectively enrolled, matching for age and comorbidities
- Prospectively enrolled
- Matching for age and comorbidities
Main finding
As reported in the abstract
| Group | Value | Preserved ejection fraction (pEF) | rEF |
|---|---|---|---|
| Females | 60% | 60% | |
| Males | 60% | 60% |
Value
Females60%
Males60%
Preserved ejection fraction (pEF)
Females60%
Males— not stated in the abstract
rEF
Females— not stated in the abstract
Males60%
Observational data: associations, not effects.
Further findings
Mortality with severe TR
| HR (95% CI) | P value | ||
|---|---|---|---|
| Severe TRWomen with pEF | 2.341 (1.075–5.098) | P = 0.032 | |
| Severe TRMen with rEF | 3.163 (1.675–5.973) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
| Outcome | Women | Men |
|---|---|---|
| At least moderate TR | 42% | 29% |
At least moderate TR
- No significant differences regarding TR aetiology
Mortality with severe TR
- Only a non-significant trend in the opposite cohorts
- Findings consistent even after matching
Hospitalisations
- Severe TR associated with hospitalisations in both HF cohorts and with cardiovascular hospitalisation in male patients, but not female patients with HF
Original publication
Sex differences in the prevalence and prognosis of tricuspid regurgitation among patients with heart failure. Heart. Published 24 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →