Heart failure & cardiomyopathies
Sex-Related Pathophysiological Mechanisms May Be Present Before Symptoms of HFpEF Develop
Authors' conclusion
Markers of elevated cardiovascular stiffness and vascular resistance are seen in female versus male participants with pre-HFpEF, suggesting that sex-related pathophysiological mechanisms are present before symptoms of HF develop.
Study context
- Population
- Patients with pre-HFpEF (asymptomatic with normal ejection fraction, elevated natriuretic peptides and structural or functional heart disease)patients with pre-HFpEF enrolled
- Participants
- 250 patients
- Comparison
- Female versus male participants with pre-HFpEF
Primary result
As reported in the abstract
P < 0.001
Further findings
LDL-cholesterol · baseline · higher in females
P < 0.001
EAE · baseline · higher in females
P < 0.001
LVSId · baseline · higher in females
P < 0.001
SVR · baseline · higher in females
P = 0.001
LVEDP · baseline · higher in females
P < 0.001
NT-proBNP · baseline · higher in females
P < 0.001
TAC · baseline · lower in females
P < 0.001
- LDL-cholesterol: adjusted for age, hypertension, diabetes, obesity and vascular disease
- Effective arterial elastance (EAE): adjusted for age, hypertension, diabetes, obesity and vascular disease
- Systemic vascular resistance (SVR): adjusted for age, hypertension, diabetes, obesity and vascular disease
- Left ventricular end diastolic pressure (LVEDP): adjusted for age, hypertension, diabetes, obesity and vascular disease
- LVSId: adjusted for age, hypertension, diabetes, obesity and vascular disease
Baseline characteristics
- Median age
- 72.0 [IQR 68.0; 77.0] years
- Female
- 38.4%
- Both sexes had a similar age, blood pressure, HbA1c, renal function and H2FPEF score
- Fewer female participants had a diagnosis of diabetes and coronary artery disease
Original publication
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