Valvular & structural heart disease
Sex-Specific Differences in Upstream Cardiac Damage in Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement (TAVR)
Authors' conclusion
The pattern of cardiac damage secondary to AS differed by sex. In early stages of cardiac damage, women had a lower 5-year mortality than men, whereas in more advanced stages, mortality was comparable between sexes.
Study context
- Population
- Patients with symptomatic aortic stenosis (AS) undergoing TAVR, August 2007–June 2022
- Participants
- 2,026 patients
- Exposure
- Women vs men
- Womenn = 995
- Menn = 1,031reference
- Outcome
- Distribution of cardiac damage stages (0–4) by sex on pre-TAVR echocardiography, and all-cause mortality by stage
- Follow-up
- 5 years
Main finding
As reported in the abstract
Cardiac damage stage distribution
Stage 0
Stage 1
Stage 2
Stage 3
Stage 4
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (95% CI) | |
|---|---|---|
| 5-year all-cause mortality per stage increase (linear trend) · 5 years — Women · for linear trend | 1.43 (1.28–1.60) | |
| 5-year all-cause mortality per stage increase (linear trend) · 5 years — Men · for linear trend | 1.26 (1.14–1.38) | |
| 0.512Adjusted hazard ratio (log scale) |
5-year mortality, women vs men, by stage
- Female sex associated with lower 5-year mortality in early stages (0, 1 or 2) but not in advanced stages (3 or 4)
Original publication
Sex-Specific Differences in Upstream Cardiac Damage in Patients With Aortic Stenosis Undergoing TAVR. JACC Cardiovasc Interv. Published 27 May 2024. doi:10.
Summarised from the published abstract; every number is checked against it