Acute cardiac care & resuscitation
Sex-Specific Outcome Following Targeted Blood Pressure, Oxygenation, and Fever Control After Out-of-Hospital Cardiac Arrest
Primary result · 1-year all-cause mortalityResult — go to the resultHazard ratio 1.27 95% CI 0.96–1.69Authors' conclusion
Among comatose patients following OHCA, no differences were observed between sexes in 1-year mortality or the efficacy of the blood pressure, oxygen, or temperature intervention.
Study context
- Population
- Adult comatose out-of-hospital cardiac arrest (OHCA) patients (age ≥18 years) of presumed cardiac cause, randomised to mean arterial pressure (MAP) target 63 or 77 mm Hg, arterial oxygen 9–10 or 13–14 kPa, and fever prevention for 36 or 72 hours
- Participants
- 789 patients
- Comparison
- Females vs males
- Femalesn = 152
- Primary endpoint
- All-cause mortality
- Follow-up
- 1 year
Methodological detailstwo-centre, factorial
- Two-centre
- Factorial
Primary result
1-year all-cause mortality
Hazard ratio
1.27
95% CI 0.96–1.69
By group
Females vs Males
HR 1.27 (95% CI 0.96–1.69)
As reported in the abstract
Further findings
Baseline age and ischemic heart disease
Ischemic heart disease Females 12% · Males 24%
Effect of MAP, oxygenation and fever-control interventions on mortality, by sex
- None of the targeted interventions had a statistically significant impact on mortality for either sex
- No mortality difference between sexes across the interventions
Original publication
Sex-Specific Outcome Following Targeted Blood Pressure, Oxygenation, and Fever Control After Out-of-Hospital Cardiac Arrest. JACC Adv. Published 20 August 2025. doi:10.
Summarised from the published abstract; every number is checked against it