Heart failure & cardiomyopathies
Sex-Specific Outcomes of Candidates Listed as the Highest Priority Status for Heart Transplantation
Main finding · Rate of HTResult — go to the resultAdjusted hazard ratio 0.74 95% CI 0.62–0.88Authors' conclusion
Women have a lower rate of HT and higher rate of delisting for death or clinical deterioration at the highest urgent status, which appears to be mediated but not fully explained by calculated panel reactive antibody levels.
Study context
- Population
- Adult single-organ heart transplantation (HT) waitlist candidates listed as Status 1 after the 2018 US allocation system change (October 18, 2018 through March 31, 2022)23.8% women
- Participants
- 1,120 candidates
- Exposure
- Women vs men listed as Status 1 for HT
- Outcome
- Rate of HT by sex (competing event: waitlist removal for death or clinical deterioration)
Methodological detailsmultivariable competing risk analysis
- Multivariable competing risk analysis
Main finding
Rate of HT
Adjusted hazard ratio
0.74
95% CI 0.62–0.88
P < 0.001
Womenvs Men
adjusted HR 0.74 (95% CI 0.62–0.88); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (95% CI) | P value | |
|---|---|---|---|
| Delisting for death or medical unsuitability | 1.48 (1.05–2.09) | P = 0.026 | |
| 0.512Adjusted hazard ratio (log scale) |
Post-HT survival of Status 1 candidates by sex
- Post-HT survival by sex similar (adjusted HR 1.13, 95% CI 0.62-2.06)
- P = 0.70
Original publication
Sex-Specific Outcomes of Candidates Listed as the Highest Priority Status for Heart Transplantation. Circ Heart Fail. Published 26 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →