Heart failure & cardiomyopathies
Sex-Specific Outcomes of Left Bundle Branch Area Pacing (LBBAP) Versus Biventricular Pacing: Results From I-CLAS
Main finding · Death or HFH, womenResult — go to the resultHazard ratio 0.64 95% CI 0.43–0.97Authors' conclusion
Women obtained significantly greater reductions in the combined endpoint of death or HFH (primarily driven by reduction in HFH) with LBBAP compared with BVP among patients requiring CRT than did men.
Study context
- Population
- Patients undergoing cardiac resynchronization therapy (CRT) (575 female, 1203 male)575 female, 1203 male
- Participants
- 1,778 patients
- Exposure
- LBBAP-CRT vs BVP-CRT, by sex
- Outcome
- Death or HF hospitalisation (heart failure hospitalization (HFH))
Methodological detailsinternational, sex-specific survival analysis
- International
- Sex-specific survival analysis
Main finding
Death or HFH, women
Hazard ratio
0.64
95% CI 0.43–0.97
P = 0.03
LBBAPvs BVP
HR 0.64 (95% CI 0.43–0.97); P = 0.03
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| HFH alone, women60% reduction | 0.4 (0.24–0.69) | P < 0.01 | |
| Death or HFH, women, by subgroupLBBAPvs BVPNonischemic cardiomyopathy | 0.45 (0.26–0.79) | P < 0.01 | |
| Death or HFH, women, by subgroupLBBAPvs BVPLBBB | 0.49 (0.27–0.87) | P < 0.01 | |
| 0.20.5125Hazard ratio (log scale) |
Echocardiographic outcomes
- Sex-specific echocardiographic outcomes better in women than men
Original publication
Sex-Specific Outcomes of LBBAP Versus Biventricular Pacing: Results From I-CLAS. JACC Clin Electrophysiol. Published 3 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →