Heart failure & cardiomyopathies
Association of Longer Leukocyte Telomere Length With Cardiac Size, Function, and Heart Failure
Main finding · Incident HFResult — go to the resultHazard ratio 0.86 95% CI 0.81–0.91Authors' conclusion
In this cross-sectional study, longer LTL was associated with a larger heart with better cardiac function in middle age, which could potentially explain the observed lower risk of incident HF.
Study context
- Population
- UK Biobank participants recruited 2006–2010 with CMR imaging; mean age 55.1 years, 48.3% men
- Participants
- 40,459 participants
- Exposure
- Longer vs shorter leukocyte telomere length (LTL)
- Outcome
- Cardiovascular imaging traits (CMR) and heart failure (HF)
Methodological detailspopulation-based, mendelian randomization, Data analyzed January to May 2023, LTL measured by quantitative PCR; CMR measurements derived using machine learning
- Population-based
- Mendelian randomization
- Data analyzed January to May 2023
- LTL measured by quantitative PCR; CMR measurements derived using machine learning
Main finding
Incident HF · median follow-up 12.0 years
Hazard ratio
0.86
95% CI 0.81–0.91
P = 1.8 × 10-6
LTL fourth quartilevs LTL first quartile
HR 0.86 (95% CI 0.81–0.91); P = 1.8 × 10-6
As reported in the abstract
Observational data: associations, not effects.
Further findings
Mendelian randomization
- Potential causal association between LTL and LV mass, global ventricular volume and LV stroke volume
Original publication
Association of Longer Leukocyte Telomere Length With Cardiac Size, Function, and Heart Failure. JAMA Cardiol. Published 1 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →