Valvular & structural heart diseaseCohort study
Sex-Specific Prognosis of Left Ventricular Size and Function Following Repair of Degenerative Mitral Regurgitation
- Retrospective cohort study
- single-centre
Authors' conclusion
After mitral valve repair, women have a higher risk for all-cause mortality at lower LVESD and LVESDi and higher EF.
Study context
- Population
- Consecutive patients undergoing isolated mitral valve repair for degenerative mitral regurgitation (MR), single institution, 1994–2016344 (7.5%) died
- Participants
- 4,589 patients
- Exposure
- Women vs men: mortality by preoperative left ventricular end-systolic dimension (LVESD), LVESDi and ejection fraction (EF)
- Womenn = 1,825
- Outcome
- Long-term all-cause mortality by preoperative LV systolic dimensions and EF, women vs men
- Follow-up
- Median 7.2 years
Main finding
As reported in the abstract
All-cause mortality: inflection points of risk
EF inflection point
| Outcome | Women | Men |
|---|---|---|
| LVESD inflection point | 3.6 cm | Not reported in the abstract |
| LVESDi inflection point | 1.8 cm/m² | 2.1 cm/m² |
Observational data: associations, not effects.
Original publication
Sex-Specific Prognosis of Left Ventricular Size and Function Following Repair of Degenerative Mitral Regurgitation. J Am Coll Cardiol. Published 16 January 2024. doi:10.1016/j.jacc.2023.10.033
Summarised from the published abstract; every number is checked against it