Heart failure & cardiomyopathies
Sex-specific prognostic thresholds of left ventricular hypertrophy in fabry disease
Authors' conclusion
In FD patients, sex-specific prognostic thresholds of LVH were identified, with women experiencing cardiovascular events at significantly lower values of LVMWT than men, even after accounting for BSA.
Study context
- Population
- Patients with Fabry disease (FD) with echocardiographic datapatients with FD (57% women)
- Participants
- 347 patients
- Exposure
- Sex-differences in the association between left ventricular hypertrophy (LVH) degree and cardiovascular outcomes in FD
- Outcome
- LV wall thickness and LV mass (also indexed for BSA)
Main finding
As reported in the abstract
- Women had lower LV wall thickness and LV mass than men, also indexing for body surface area (BSA)
- all P < 0.001
Observational data: associations, not effects.
Further findings
Composite-event rate · 8 years · significantly higher in men
P = 0.015
| Outcome | Women | Men |
|---|---|---|
| LVMWT prognostic threshold for the composite endpoint | LVMWT threshold > 10 mm | LVMWT threshold 13 mm |
| Indexed LVMWT | > 6.1 mm/m² | 6.9 mm/m² |
- Left ventricular maximal wall thickness (LVMWT) prognostic threshold for the composite endpoint — Thresholds associated with increased risk of the composite endpoint
- both P < 0.001
- LVMWT prognostic threshold for the composite endpoint: independently associated with outcomes, after adjustment for age, exposure to specific therapy and renal function
Composite of mortality, hospitalization for heart failure, atrial fibrillation, major brady- or tachy-arrhythmias and ischaemic stroke · median follow-up of 53 (IQR: 26-90) months
- Patients meeting the study endpoint
- 64 patients (18%)
Original publication
Sex-specific prognostic thresholds of left ventricular hypertrophy in fabry disease. Eur Heart J Cardiovasc Imaging. Published 25 September 2025. doi:10.
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