Arrhythmias & electrophysiologyCohort study
Two-year outcomes of Micra AV leadless pacemakers in the Micra AV CED study
- Retrospective cohort study
- propensity score overlap weight-adjusted
- Medicare administrative claims data
Authors' conclusion
Patients implanted with Micra AV had lower complications and re-intervention rates at 2 years than patients implanted with a traditional DC-TV pacemaker. All-cause mortality remained higher in Micra AV patients, likely due to their higher comorbidity burden and other differences in baseline characteristics.
Study context
- Population
- US Medicare patients implanted with a pacemaker in 2020 and 2021
- Participants
- 7,552 vs 110,558
- Exposure
- Micra AV leadless pacemaker vs dual-chamber transvenous pacemaker
- Micra AVn = 7,552
- Dual-chamber transvenous (DC-TV)n = 110,558reference
- Outcome
- Chronic complications, re-interventions and all-cause mortality
- Follow-up
- 2 years
Main finding
As reported in the abstract
2 years post-implant
Micra AV
5.3%
Complications (adjusted) · Re-intervention (adjusted) 3.5%
DC-TV
9.6%
Complications (adjusted) · Re-intervention (adjusted) 5.6%
Micra AV vs DC-TVHazard ratio (95% CI)P value
complications
0.54(0.49–0.61)
P < 0.0001re-intervention
0.62(0.54–0.72)
P < 0.0001all-cause mortality, unadjusted
2.48(2.35–2.62)
P < 0.0001all-cause mortality, adjusted
1.53(1.44–1.62)
P < 0.0001Observational data: associations, not effects.
Further findings
Upgrade to cardiac resynchronization therapy · 2 years · adjusted
P = 0.40
- Micra AV upgrade to dual-chamber system · 2 years
- 1.4%
Original publication
Two-year outcomes of Micra AV leadless pacemakers in the Micra AV CED study. Europace. Published 1 November 2024. doi:10.1093/europace/euae273
Summarised from the published abstract; every number is checked against it