Valvular & structural heart disease
Shorter Time to Transcatheter Aortic Valve Implantation Is Associated With Improved Outcomes in Acute Decompensated Aortic Stenosis
Main finding · Heart failure hospitalization or all-cause mortality (primary composite outcome)Result — go to the resultHazard ratio 1.09 95% CI 1.04–1.16Authors' conclusion
In patients with acute decompensated aortic stenosis, longer time to TAVI was associated with an increased risk of adverse events at mid-term follow-up.
Study context
- Population
- Patients with their first presentation of acute decompensated aortic stenosis who underwent an urgent transcatheter aortic valve implantation (TAVI) during their index admission
- Participants
- 276 patients
- Exposure
- Time to TAVI, per 5 days
- Outcome
- Heart failure hospitalization or all-cause mortality (primary composite outcome)
- Follow-up
- 4.6 (3.6-5.7) years
Main finding
As reported in the abstract
Hazard ratio
1.09
95% CI 1.04–1.16
P = 0.001
Time to TAVI, every 5 days
hazard ratio 1.09 (95% CI 1.04–1.16); P = 0.001
Every 5 days, as printed
- Primary outcome occurred
- 58%
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Hazard ratio (95% CI) | P value | |
|---|---|---|---|
| Heart failure hospitalization or cardiovascular mortality (secondary composite outcome) · follow-up of 4.6 (3.6-5.7) years | 1.08 (1.01–1.16) | P = 0.023 | |
| 0.512Hazard ratio (log scale) |
- Heart failure hospitalization or cardiovascular mortality (secondary composite outcome) — Secondary outcome occurred
- 35%
- Heart failure hospitalization or cardiovascular mortality (secondary composite outcome): adjusted for comorbidities, mean gradient, and cardiopulmonary organ support
Baseline characteristics
- Age
- 84 (79-88) years
- Male sex
- 63.7%
- Patients requiring cardiopulmonary organ support
- 3.6%
- Aortic valve area
- 0.7 (0.5-0.8) cm 2
- Left ventricular ejection fraction
- 55 (37-57)%
- Median time to TAVI
- 22 [13-32] days
- Baseline characteristics were similar between patients stratified according to the median time to TAVI
Original publication
Shorter Time to Transcatheter Aortic Valve Implantation Is Associated With Improved Outcomes in Acute Decompensated Aortic Stenosis. Circ Cardiovasc Interv. Published 23 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →