Significance of Persistent Inflammation in Patients With Chronic Coronary Syndrome: Insights From the REAL-CAD Study
Authors' conclusion
The study shows that persistent low-grade inflammation is associated with poor outcomes
Study context
- Population
- Japanese patients with chronic coronary syndrome in REAL-CAD, event-free to 6 months with high-sensitivity C-reactive protein (hs-CRP) at baseline and 6 months
- Participants
- 10,460 patients
- Comparison
- Persistently high, elevated or reduced hs-CRP vs persistently low hs-CRP
- Primary endpoint
- CV mortality, MI, stroke and unstable angina hospitalization
Methodological detailsprespecified subanalysis, landmark analysis
- Prespecified subanalysis
- Landmark analysis
Primary result
As reported in the abstract
Each group vs persistently lowEstimate (95% CI)P value
Persistently high
adjusted HR 1.48(1.18–1.89)
P = 0.001Elevated
HR 1.07(0.77–1.49)
P = 0.68Reduced
HR 0.92(0.66–1.27)
P = 0.60Original publication
Significance of Persistent Inflammation in Patients With Chronic Coronary Syndrome: Insights From the REAL-CAD Study. JACC Adv. Published 5 June 2024. doi:10.
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