Acute cardiac care & resuscitation
The significance of possible non-occlusive mesenteric ischemia in relation to neurological outcomes in patients with refractory cardiac arrest – Secondary analysis of the Prague OHCA study
Authors' conclusion
The development of profuse diarrhea, abdominal distension and other signs suggesting non-occlusive mesenteric ischemia in patients with refractory out-of-hospital cardiac arrest are observed more frequently in patients with poor neurological outcome at day 180, especially in patients treated with ECPR.
Study context
- Population
- Patients with refractory out-of-hospital cardiac arrest who survived longer than one hour after hospital admission
- Participants
- 256 study participants
- Comparison
- Possible non-occlusive mesenteric ischemia (NOMI) correlated with neurologically unfavorable outcome (Cerebral Performance Category (CPC) 3-5) at 180 days; ECPR vs. CPR approaches
Methodological detailssecondary analysis
- Secondary analysis
Primary result
As reported in the abstract
Possible NOMI · onset within 12 h of admission
P > 0.01
- Patients developing possible NOMI
- 61
Further findings
Adverse neurological outcomes among patients with possible NOMI · 180 days · of patients with possible NOMI in each group
Correlates of possible NOMI
- Its occurrence correlated with cardiac arrest length, elevated levels of neuron-specific enolase and procalcitonin at 48 and 72 h
- It was independently associated with adverse outcomes
Cox regression: possible NOMI and poor neurological outcomes
- Possible NOMI was associated with poor neurological outcomes in ECPR patients
Original publication
The significance of possible non-occlusive mesenteric ischemia in relation to neurological outcomes in patients with refractory cardiac arrest – Secondary analysis of the Prague OHCA study. Resuscitation. Published 15 May 2025. doi:10.
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