Heart failure & cardiomyopathies
Skeletal Muscle Mitochondrial Respiration and Exercise Intolerance in Patients With Heart Failure With Preserved Ejection Fraction
Authors' conclusion
In this study, patients with HFpEF had marked abnormalities in skeletal muscle mitochondrial function.
Study context
- Population
- Clinically stable older adults (>60 years) with chronic heart failure with preserved ejection fraction (HFpEF) and age-matched healthy controls, not in regular exercise or diet programs
- Participants
- 72 adults
- Exposure
- HFpEF vs age-matched healthy controls
- Outcome
- Skeletal muscle mitochondrial function (maximal capacity, complex I- and complex II-linked respiration) and its association with exercise performance (peak VO2, 6-minute walk distance, SPPB)
Methodological detailsage-matched controls, single university referral centre, Data collected March 2016 to December 2017; analysed November 2020 to May 2021
- Age-matched controls
- Single university referral centre
- Data collected March 2016 to December 2017; analysed November 2020 to May 2021
Main finding
As reported in the abstract
Maximal capacity correlated with peak exercise oxygen consumption
R = 0.69
P < .001
Maximal capacity correlated with 6-minute walk distance
R = 0.70
P < .001
Maximal capacity correlated with Short Physical Performance Battery score
R = 0.46
P < .001
Observational data: associations, not effects.
Original publication
Skeletal Muscle Mitochondrial Respiration and Exercise Intolerance in Patients With Heart Failure With Preserved Ejection Fraction. JAMA Cardiol. Published 1 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →