Cohort study
Vigorous Exercise in Patients With Hypertrophic Cardiomyopathy
- Prospective cohort study
- investigator-initiated
- multicenter
- observational registry
- 42 hypertrophic cardiomyopathy (HCM) centers in the US and internationally
Authors' conclusion
Results of this cohort study suggest that among individuals with HCM or those who are genotype positive/phenotype negative and are treated in experienced centers, those exercising vigorously did not experience a higher rate of death or life-threatening arrhythmias than those exercising moderately or those who were sedentary.
Study context
- Population
- Individuals aged 8 to 60 years with HCM or genotype positive/phenotype negative, without conditions precluding exercise
- Participants
- 1,660 individuals
- Exposure
- Vigorous exercise vs nonvigorous activity
- Vigorousn = 699
- Outcome
- Composite of:
- Death
- Resuscitated sudden cardiac arrest
- Arrhythmic syncope
- Appropriate ICD shock
Main finding
As reported in the abstract
Adjusted hazard ratio
1.01
95% 1-sided CI upper 1.48
Events by group
Observational data: associations, not effects.
Original publication
Vigorous Exercise in Patients With Hypertrophic Cardiomyopathy. JAMA Cardiol. Published 1 June 2023. doi:10.1001/jamacardio.2023.1042
Summarised from the published abstract; every number is checked against it