Cardio-oncology & otherCohort study
Social determinants of health in cancer survivors and the risk of cardiovascular events
- Retrospective cohort study
- propensity-score matched
Authors' conclusion
Among cancer survivors, unfavourable SDoH was associated with elevated CVD risk, whereas favourable SDoH attenuated this risk to levels comparable with non-cancer population.
Study context
- Population
- Cancer survivors and propensity score matched non-cancer controls, UK Biobank18,992 survivors · 75,968 controls
- Exposure
- Unfavourable or medium vs favourable social determinants of health (SDoH) in cancer survivors
- Outcome
- Incident cardiovascular disease (CVD) (ischaemic heart disease (IHD), heart failure (HF), stroke, CVD mortality)
Main finding
As reported in the abstract
CVD
Each group vs favourable SDoHHazard ratio (95% CI)
Medium SDoH
1.17(1.09–1.27)
Unfavourable SDoH
1.32(1.23–1.43)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| IHD, HF, stroke, CVD mortality — Unfavourable SDoH vs Favourable SDoH · IHD | 1.31 (1.15–1.49) | |
| IHD, HF, stroke, CVD mortality — Unfavourable SDoH vs Favourable SDoH · HF | 1.58 (1.30–1.92) | |
| IHD, HF, stroke, CVD mortality — Unfavourable SDoH vs Favourable SDoH · stroke | 1.47 (1.18–1.84) | |
| IHD, HF, stroke, CVD mortality — Unfavourable SDoH vs Favourable SDoH · CVD mortality | 1.54 (1.25–1.90) | |
| CVD, survivors with favourable SDoH vs matched non-cancer controls — Favourable SDoH vs Non-cancer controls · overall CVD risk | 1.07 (1.00–1.13) | |
| CVD, survivors with favourable SDoH vs matched non-cancer controls — Favourable SDoH vs Non-cancer counterparts · joint analysis | 1.22 (1.15–1.28) | |
| 0.512Hazard ratio (log scale) |
Original publication
Social determinants of health in cancer survivors and the risk of cardiovascular events. Eur J Prev Cardiol. Published 3 October 2025. doi:10.1093/eurjpc/zwaf633
Summarised from the published abstract; every number is checked against it