Sodium-Glucose Cotransporter 2 Inhibitors Preceding ST-Segment Elevation Myocardial Infarction: Global Proteomics and Pathobiological Insights
Authors' conclusion
SGLT2i appears to predominantly associate with up-regulation of heme-scavenging and nitric oxide, and plausibly through a related reduction in infarct size also associates with the observed related improvement in post infarction heart failure.
Study context
- Population
- Consecutive STEMI patients with diabetes, on and not on SGLT2i prior to STEMI, blood collected at arterial sheath insertion between June 2021 and October 2023STEMI patients, 149 eligible patients had diabetes, 33 propensity-matched pairs
- Participants
- 560 patients
- Comparison
- Differentially regulated proteins between the 2 SGLT2i groups
- SGLT2i+n = 35
- SGLT2i-n = 114
- Outcome
- Presenting demographics and reperfusion strategies
Methodological detailsconsecutive STEMI patients, liquid chromatography-tandem mass spectrometry
- Consecutive STEMI patients
- Liquid chromatography-tandem mass spectrometry
Main finding
As reported in the abstract
- Both SGLT2i groups were comparable in their presenting demographics and reperfusion strategies, except for higher proportion of insulin use in SGLT2i+ patients
Further findings
- Propensity-matched pairs
- Thirty-three
- Differentially expressed proteins
- 21
- Up-regulation of proteins involved in heme-scavenging and nitric oxide transport in patients on SGLT2i+
Original publication
Sodium-Glucose Cotransporter 2 Inhibitors Preceding ST-Segment Elevation Myocardial Infarction: Global Proteomics and Pathobiological Insights. JACC Adv. Published 18 June 2025. doi:10.
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