Discovery of plasma proteins associated with ventricular fibrillation during first ST-elevation myocardial infarction via proteomics
Authors' conclusion
Ventricular fibrillation due to first STEMI was significantly associated with two up-regulated proteins (ACTBL2 and F13A1), suggesting that they may represent novel underlying molecular VF mechanisms.
Study context
- Population
- Danish patients with first ST-elevation myocardial infarction (STEMI) undergoing primary PCI229 analysed
- Participants
- 230 patients
- Comparison
- STEMI with ventricular fibrillation (VF) vs without VF
- VFn = 110
- No VFn = 120reference
- Outcome
- Plasma proteins associated with VF
- Follow-up
- Plasma within 24 h of symptom onset
Methodological detailsmass spectrometry-based proteomics, Median 257 proteins (IQR 244-281) quantified per patient
- Mass spectrometry-based proteomics
- Median 257 proteins (IQR 244-281) quantified per patient
Main finding
As reported in the abstract
Proteins significantly associated with VF after multiple-testing correction
Fold change
2.25
P < 0.001
ACTBL2, up-regulated; q = 0.023
Fold change
1.48
P < 0.001
F13A1, up-regulated; q = 0.023
- Proteins associated with VF (before correction; coagulation, haemostasis, immunity)
- 26
Observational data: associations, not effects.
Further findings
Correlation with anterior infarct location
- None of the proteins correlated with anterior infarct location
Original publication
Discovery of plasma proteins associated with ventricular fibrillation during first ST-elevation myocardial infarction via proteomics. Eur Heart J Acute Cardiovasc Care. Published 9 October 2023. doi:10.
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