Heart failure & cardiomyopathies
Spinal Stenosis and Carpal Tunnel Syndrome as Surrogates of Transthyretin Amyloid Cardiomyopathy
Authors' conclusion
LSS and CTS were associated with increased likelihood of cardiovascular events and amyloidosis diagnosis. This highlight the importance of a dedicated assessment of cardiovascular symptoms for LSS/CTS patients, particularly if both conditions are present.
Study context
- Population
- Patients aged 50–90 years with lumbar spinal stenosis (LSS)/carpal tunnel syndrome (CTS) diagnosis between 1995 and 2015, identified through Rochester Epidemiology Project (Minnesota, USA)LSS and CTS cohorts with matched controls
- Participants
- 6,076 / 16,205 / 6,664 / 17,462
- Exposure
- LSS and CTS cases vs age- and sex-matched controls
- LSS casesn = 6,076
- LSS controlsn = 16,205reference
- CTS casesn = 6,664
- CTS controlsn = 17,462reference
- Outcome
- Baseline comorbidities and cardiac events
Methodological detailsage- and sex-matched controls (3 per case)
- Age- and sex-matched controls (3 per case)
Main finding
As reported in the abstract
- LSS and CTS cases had more comorbidities at baseline and higher likelihood of cardiac events compared to controls
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| SurvivalLSS casesvs LSS controlsWorse survival in LSS cases | 1.26 (1.19–1.33) | P < 0.001 | |
| SurvivalCTS casesvs CTS controlsSimilar survival | 0.95 (0.90–1.01) | P = 0.10 | |
| 0.512Hazard ratio (log scale) |
Amyloidosis diagnosis · 10-year — LSS cases vs LSS controls
cause-specific HR 2.18 · P < 0.001
| Outcome | Cause-specific HR | P value |
|---|---|---|
| Amyloidosis diagnosis · 10-yearCTS cases vs CTS controls | 2.87 | P < 0.001 |
Amyloidosis incidence in patients with both LSS and CTS · 10-year
- 10-year incidence rate of amyloidosis, patients with both LSS and CTS
- 1.45%
Original publication
Spinal Stenosis and Carpal Tunnel Syndrome as Surrogates of Transthyretin Amyloid Cardiomyopathy. JACC Adv. Published 20 January 2026. doi:10.
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