Valvular & structural heart disease
Impact of Intraprocedural Mitral Regurgitation and Gradient Following Transcatheter Edge-to-Edge Repair for Primary Mitral Regurgitation
Authors' conclusion
Intraprocedural rMR but not MPG independently predicted clinical outcomes following TEER for primary MR.
Study context
- Population
- Patients with primary mitral regurgitation (MR) undergoing transcatheter edge-to-edge repair (TEER), 2008–2022Residual mitral regurgitation (rMR) and MPG available
- Participants
- 1,509 patients
- Exposure
- Intraprocedural residual MR and mean mitral gradient categories after TEER
- Outcome
- All-cause mortality or HF hospitalization
- Follow-up
- 2 years
Methodological detailsmulticentre, consecutive patients, 27 international sites
- Multicentre
- Consecutive patients
- 27 international sites
Main finding
As reported in the abstract
Hazard ratio (95% CI)P value
rMR ≥2+ vs rMR ≤1+
1.87(1.32–2.65)
P < 0.001High gradient vs Low gradient
0.78(0.47–1.31)
P = 0.35Observational data: associations, not effects.
Further findings
Optimal result/low gradient achieved
- Patients with optimal result/low gradient
- 1,039
Original publication
Impact of Intraprocedural Mitral Regurgitation and Gradient Following Transcatheter Edge-to-Edge Repair for Primary Mitral Regurgitation. JACC Cardiovasc Interv. Published 8 July 2024. doi:10.
Summarised from the published abstract; every number is checked against it