Arrhythmias & electrophysiology
Stereotactic Body Radiation Therapy for Ventricular Tachycardia (VT) in Chagas Cardiomyopathy: A Prospective Phase I/II Pilot Study
Authors' conclusion
SBRT is a feasible approach for refractory VT in Chagas cardiomyopathy. Despite a high rate of VT recurrence, SBRT statistically significantly reduced the burden of ventricular arrhythmia, warranting further investigation.
Study context
- Population
- Patients with Chagas cardiomyopathy and refractory VT who had failed or were ineligible for catheter ablationpatients with implantable cardioverter-defibrillators, 9 of whom had prior failed ablations
- Participants
- 11 patients
- Exposure
- 12 months after stereotactic body radiation therapy (SBRT) vs 6 months before SBRT
- SBRTn = Eleven
- Outcome
- Reduction in VT burden and treatment-related adverse events
- Follow-up
- 12 months after SBRT vs 6 months before SBRT
Methodological detailssingle 25-Gy fraction of SBRT
- Single 25-Gy fraction of SBRT
Main finding
As reported in the abstract
- Reduction in burden of VT episodes
- P = 0.040
- Reduction in antitachycardia pacing therapies
- P = 0.012
- Reduction in combined antitachycardia pacing/shocks
- P = 0.022
Observational data: associations, not effects.
Further findings
Target volumes
cm³
- Median internal target volume
- 27.3
- Planning target volume
- 91.1
VT recurrence · median follow-up of 160 days
- VT recurred in patients
- 10
- Median time to recurrence after a 6-week blanking period
- 79 days (IQR: 51.5-167)
Overall survival · 12 months
- 12-month overall survival
- 45.5%
- The patient without recurrence died of noncardiac causes 22 days after SBRT
Original publication
Stereotactic Body Radiation Therapy for VT in Chagas Cardiomyopathy: A Prospective Phase I/II Pilot Study. JACC Clin Electrophysiol. Published 11 September 2026. doi:10.
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