Arrhythmias & electrophysiology
Stroke Prevention With Prophylactic Left Atrial Appendage Occlusion in Cardiac Surgery Patients Without Atrial Fibrillation: A Meta-Analysis of Randomized and Propensity-Score Studies
Pooled result · CVAResult — go to the resultHazard ratio 0.65 95% CI 0.45–0.94Authors' conclusion
In this meta-analysis of patients without previous AF undergoing cardiac surgery, LAAO was associated with a decreased risk of CVA, no difference in the incidence of postoperative atrial fibrillation, and a significant overall survival benefit at a 4-year landmark analysis.
Study context
- Population
- Patients without previous atrial fibrillation (AF) (normal sinus rhythm) undergoing cardiac surgery
- Participants
- 4,130 patients6 studies
- Comparison
- Concomitant left atrial appendage occlusion (LAAO) vs no LAAO during cardiac surgery
- LAAOn = 2,146
- no-LAAOn = 1,984reference
- Outcome
- Incidence of cerebrovascular accidents (CVAs)
Pooled result
CVA · 5 years
Hazard ratio
0.65
95% CI 0.45–0.94
P = 0.022
By group
no-LAAO
6.8±1.0%
LAAO
4.3±0.8%
LAAOvs no-LAAO
HR 0.65 (95% CI 0.45–0.94); P = 0.022
As reported in the abstract
Further pooled results
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Postoperative AF | 1.05 (0.86–1.28) | P = 0.628 | |
| 0.512Relative risk (log scale) |
| Outcome | LAAO | no-LAAO | P value |
|---|---|---|---|
| Overall survival (landmark analysis) · 4 years | 89.6±11.0% | 86±12.2% | P = 0.041 |
Original publication
Stroke Prevention With Prophylactic Left Atrial Appendage Occlusion in Cardiac Surgery Patients Without Atrial Fibrillation: A Meta-Analysis of Randomized and Propensity-Score Studies. Circ Cardiovasc Interv. Published 11 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →