Arrhythmias & electrophysiology
Clinical impact of surgical left atrial appendage occlusion during cardiac surgery in patients in sinus rhythm: A meta-analysis
Authors' conclusion
This meta-analysis has demonstrated an improved freedom from cerebrovascular events and a midterm survival benefit in sinus rhythm patients undergoing cardiac surgery and surgical LAAO. This meta-analysis does not demonstrate an increased occurrence of postoperative atrial fibrillation in the LAAO group.
Study context
- Population
- Sinus rhythm patients undergoing cardiac surgery
- Participants
- 2,742 patients6 studies
- Comparison
- Surgical left atrial appendage occlusion (LAAO) vs no LAAO during cardiac surgery
- Outcome
- Postoperative AF (early); freedom from cerebrovascular events and midterm survival (late)
Methodological detailsreconstructed individual time-to-event patient data from Kaplan-Meier curves
- Reconstructed individual time-to-event patient data from Kaplan-Meier curves
Pooled result
As reported in the abstract
LAAO vs no-LAAOEstimate (95% CI)P value
Postoperative AF; I2 = 46%
OR 1.157(0.904–1.481)
P = 0.246Cerebrovascular events
HR 0.482(0.361–0.643)
P < 0.001Midterm survival
HR 0.701(0.554–0.886)
P = 0.003Original publication
Clinical impact of surgical left atrial appendage occlusion during cardiac surgery in patients in sinus rhythm: A meta-analysis. Heart Rhythm. Published 23 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →