Heart failure & cardiomyopathies
Subclinical left ventricular systolic dysfunction and incident stroke in the elderly: long-term findings from Cardiovascular Abnormalities and Brain Lesions
Main finding · Ischaemic strokeResult — go to the resultHazard ratio 2.69 95% CI 1.47–4.92Authors' conclusion
LV GLS was a strong independent predictor of ischaemic stroke in a predominantly elderly stroke-free cohort.
Study context
- Population
- Stroke-free, predominantly elderly participants of the Cardiac Abnormalities and Brain Lesions (CABL) study (mean age 71.4 ± 9.4 years, 60.9% women)
- Participants
- 708 participants
- Exposure
- Abnormal vs normal LV GLS
- Abnormal LV GLSn = 133
- Outcome
- Incident ischaemic stroke
- Follow-up
- Mean 10.8 ± 3.9 years
Main finding
Ischaemic stroke
Hazard ratio
2.69
95% CI 1.47–4.92
P = 0.001
Abnormal LV GLSvs Normal LV GLS
HR 2.69 (95% CI 1.47–4.92); P = 0.001
As reported in the abstract
- Cumulative incidence significantly higher with abnormal LV GLS
- P < 0.001
- Ischaemic stroke events, overall
- 47 (6.6%)
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted HR (95% CI) | P value | |
|---|---|---|---|
| Cardioembolic or cryptogenic stroke26 events | 3.57 (1.51–8.43) | P = 0.004 | |
| 0.10.31310Adjusted hazard ratio (log scale) |
Cardioembolic or cryptogenic stroke
- Not predictive of other stroke subtypes (21 events)
Original publication
Subclinical left ventricular systolic dysfunction and incident stroke in the elderly: long-term findings from Cardiovascular Abnormalities and Brain Lesions. Eur Heart J Cardiovasc Imaging. Published 28 July 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →